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KMID : 1011820210620060641
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Investigative and Clinical Urology
2021 Volume.62 No. 6 p.641 ~ p.649
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Prognostic value of preoperative neutrophil-to-lymphocyte ratio in histological variants of non-muscle-invasive bladder cancer
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Li Deng-Xiong
Wang Xiao-Ming
Tang Yin
Yang Yu-Bo
Feng De-Chao
Li Ao
Zhang Fa-Cai
Bai Yun-Jin
Han Ping
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Abstract
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Purpose: Many studies identified that the preoperative neutrophil-to-lymphocyte ratio (PNLR) was associated with patient prognosis in non-muscle-invasive bladder cancer (NMIBC). We hypothesized that PNLR could be prognostic in patients with histological variants of NMIBC (VH-NMIBC).
Materials and Methods: This retrospective study included patients with VH-NMIBC admitted at our center between January 2009 and May 2019. The best cut-off value of NLR was measured by the receiver operating characteristic curve and Youden index. The Kaplan-Meier method and Cox proportional hazard regression models were employed to evaluate the association between PNLR and disease prognosis, including recurrence-free survival (RFS), progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS).
Results: A total of 243 patients with VH-NMIBC were enrolled in our study. According to the Kaplan-Meier method results, patients with PNLR ≥2.2 were associated with poor RFS (p<0.001), PFS (p<0.001), CSS (p<0.001), and OS (p<0.001). Multivariable analyses indicated that PNLR ≥ 2.2 was an independent prognostic factor of RFS (hazard ratio [HR], 2.11; 95% confidence interval [CI, 1.57?1.83; p<0.001), PFS (HR, 2.34; 95% CI, 1.70?3.21; p<0.001), CCS (HR, 2.87; 95% CI, 1.96?4.18; p< 0.001), and OS (HR, 2.83; 95% CI, 1.96?4.07; p<0.001).
Conclusions: This study identified that PNLR ≥2.2 was usually associated with a poor prognosis for patients with VH-NMIBC.
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KEYWORD
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Bladder cancer, Histology, Lymphocyte, Neutrophil, Prognosis
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